Exploring Psychedelics for Depression
Psychedelic-Assisted Therapy for Treatment-Resistant Depression?
Q: I’ve been in treatment for depression for years, both therapy and medication. Yet, I’m still struggling. I’m considering alternative treatments, including psychedelic-assisted treatment. My husband and therapist are against it. Can you help me decide?
A: We’re sorry you’re still experiencing symptoms despite years of care. Understandably, you’re considering alternative treatments. Given your situation and with the recent widespread interest in psychedelic-assisted therapy and their potential benefits for psychiatric conditions. Kentlands Psychotherapy’s own Dr. Adrian Kress shares the following thoughts as you consider your options.
Psychedelics, including psilocybin and LSD, have been studied for years for their efficacy in treating depression, anxiety, PTSD, and substance use disorders. Moreover, the interest in these compounds is partly because some patients, like yourself, do not achieve complete symptom relief with conventional treatments.
Research
In 2006, Johns Hopkins University began researching the safety and efficacy of psilocybin. Their studies and others over the past two decades have shown initial promise. In 2019, the FDA approved esketamine (classified as a Schedule III drug), a form of ketamine, for treatment-resistant depression. Esketamine is the only form of ketamine that is FDA-approved. In contrast, the U.S. classifies classic psychedelics like LSD and psilocybin as Schedule I drugs, indicating their high potential for abuse and lack of acceptance for medical use. The FDA has not approved psilocybin or other psychedelics. Some ketamine clinics offer other formulations, but the FDA has not approved these either, as they have not demonstrated efficacy in clinical trials.
Clinical
Clinical practice with patients showed mixed results in treating depression, requiring more research. As you weigh your options, consider consulting with a medical professional who specializes in psychedelic therapies and comparing their opinion with that of your treating psychiatrist. Perhaps discuss what you learned with your husband and therapist, as their concerns likely stem from a place of care and caution.
Understanding and discussing the potential risks and benefits of this treatment with your loved ones and care team will help you make a confident final decision.
Originally published in Lakelands Leader November 2024
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